ctcRbase

Entry Detail

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General Information

Database ID: BRCA49672 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SPTBN2 Full Name: spectrin beta, non-erythrocytic 2 Category: mRNA Synonyms: GTRAP41|SCA5|SCAR14 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 66685248 End Site(bp): 66729226 Gene Summary: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009] External Links: Ensembl ID: ENSG00000173898 HGNC ID: HGNC:11276 Entrez Gene: 6712

Expression Profile of SPTBN2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-339-5p YES YES YES hsa-miR-34a-5p YES NO YES hsa-miR-34c-5p YES NO YES hsa-miR-362-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-449a YES NO YES hsa-miR-449b-5p YES NO YES hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES NO YES hsa-miR-542-3p YES YES YES Display: