ctcRbase

Entry Detail

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General Information

Database ID: PAAD03201 Cancer Type: pancreatic cancer Dataset: GSE60407 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: SIM2 Full Name: SIM bHLH transcription factor 2 Category: mRNA Synonyms: HMC13F06|HMC29C01|SIM|bHLHe15 Chromosome: chr21 Strand: + Coordinate: Start Site(bp): 36699133 End Site(bp): 36749917 Gene Summary: This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] External Links: Ensembl ID: ENSG00000159263 HGNC ID: HGNC:10883 Entrez Gene: 6493

Expression Profile of SIM2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-155-5p YES YES YES hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-365a-3p YES NO YES hsa-miR-367-3p YES YES YES hsa-miR-493-3p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: