ctcRbase

Entry Detail

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General Information

Database ID: PAAD03256 Cancer Type: pancreatic cancer Dataset: GSE60407 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PPM1L Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1L Category: mRNA Synonyms: PP2C-epsilon|PP2CE|PPM1-LIKE Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 160755602 End Site(bp): 161078907 Gene Summary: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] External Links: Ensembl ID: ENSG00000163590 HGNC ID: HGNC:16381 Entrez Gene: 151742

Expression Profile of PPM1L Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-15a-5p NO NO YES hsa-miR-15b-5p NO NO YES hsa-miR-16-5p NO NO YES hsa-miR-186-5p YES YES NO hsa-miR-195-5p NO NO YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-424-5p NO NO YES hsa-miR-425-5p YES YES NO hsa-miR-497-5p NO NO YES hsa-miR-506-3p YES NO YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-532-3p YES NO YES hsa-miR-653-5p YES YES NO Display: