ctcRbase

Entry Detail

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General Information

Database ID: PRAD01489 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: E2F2 Full Name: E2F transcription factor 2 Category: mRNA Synonyms: E2F-2 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 23506430 End Site(bp): 23531220 Gene Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000007968 HGNC ID: HGNC:3114 Entrez Gene: 1870

Expression Profile of E2F2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-138-5p YES NO YES hsa-miR-155-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-218-5p YES YES NO hsa-miR-221-3p YES NO YES hsa-miR-222-3p YES NO YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-302a-3p YES NO YES hsa-miR-302b-3p YES NO YES hsa-miR-302c-3p YES NO YES hsa-miR-302d-3p YES NO YES hsa-miR-302e YES NO YES hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-326 YES NO YES hsa-miR-330-5p YES NO YES hsa-miR-365a-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-372-3p YES NO YES hsa-miR-373-3p YES NO YES hsa-miR-381-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-495-3p YES YES YES hsa-miR-496 YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES NO YES hsa-miR-520b YES NO YES hsa-miR-520c-3p YES NO YES hsa-miR-520d-3p YES NO YES hsa-miR-520e YES NO YES hsa-miR-93-5p YES YES YES hsa-miR-98-5p YES NO YES Display: