| ncRNA Symbol: | FGR | | Full Name: | FGR proto-oncogene, Src family tyrosine kinase | | Category: | mRNA | | Synonyms: | SRC2|c-fgr|c-src2|p55-Fgr|p55c-fgr|p58-Fgr|p58c-fgr | | Chromosome: | chr1 | | Strand: | - | | Coordinate: | | Start Site(bp): | 27612064 | End Site(bp): | 27635277 |
| | Gene Summary: | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] | | External Links: | |
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