| ncRNA Symbol: | HLA-DPB1 | | Full Name: | major histocompatibility complex, class II, DP beta 1 | | Category: | mRNA | | Synonyms: | DPB1|HLA-DP|HLA-DP1B|HLA-DPB | | Chromosome: | chr6 | | Strand: | + | | Coordinate: | | Start Site(bp): | 33075926 | End Site(bp): | 33087201 |
| | Gene Summary: | HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] | | External Links: | |
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