ctcRbase

Entry Detail

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General Information

Database ID: PRAD03123 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CLPB Full Name: ClpB homolog, mitochondrial AAA ATPase chaperonin Category: mRNA Synonyms: ANKCLB|HSP78|MEGCANN|MGCA7|SKD3 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 72292425 End Site(bp): 72434680 Gene Summary: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] External Links: Ensembl ID: ENSG00000162129 HGNC ID: HGNC:30664 Entrez Gene: 81570

Expression Profile of CLPB Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-141-3p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193a-5p YES NO YES hsa-miR-193b-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-223-3p YES NO YES hsa-miR-22-3p YES YES YES hsa-miR-339-5p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-494-3p YES NO YES Display: