| ncRNA Symbol: | PTPRN | | Full Name: | protein tyrosine phosphatase, receptor type N | | Category: | mRNA | | Synonyms: | IA-2|IA-2/PTP|IA2|ICA512|R-PTP-N | | Chromosome: | chr2 | | Strand: | - | | Coordinate: | | Start Site(bp): | 219289623 | End Site(bp): | 219309648 |
| | Gene Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] | | External Links: | |
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