ctcRbase

Entry Detail

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General Information

Database ID: PRAD03475 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: OTUD5 Full Name: OTU deubiquitinase 5 Category: mRNA Synonyms: DUBA Chromosome: chrX Strand: - Coordinate: Start Site(bp): 48922028 End Site(bp): 48958386 Gene Summary: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000068308 HGNC ID: HGNC:25402 Entrez Gene: 55593

Expression Profile of OTUD5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-1-3p YES NO YES hsa-miR-206 YES NO YES hsa-miR-24-3p YES YES YES hsa-miR-323a-3p YES NO YES hsa-miR-331-3p YES NO YES hsa-miR-421 YES YES NO hsa-miR-505-3p YES YES YES hsa-miR-543 YES YES NO hsa-miR-613 YES NO YES Display: