| ncRNA Symbol: | HLA-DMB | | Full Name: | major histocompatibility complex, class II, DM beta | | Category: | mRNA | | Synonyms: | D6S221E|RING7 | | Chromosome: | chr6 | | Strand: | - | | Coordinate: | | Start Site(bp): | 32934629 | End Site(bp): | 32941070 |
| | Gene Summary: | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] | | External Links: | |
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