ctcRbase

Entry Detail

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General Information

Database ID: PRAD04231 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: C9orf72 Full Name: chromosome 9 open reading frame 72 Category: mRNA Synonyms: ALSFTD|DENNL72|FTDALS|FTDALS1 Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 27546545 End Site(bp): 27573866 Gene Summary: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] External Links: Ensembl ID: ENSG00000147894 HGNC ID: HGNC:28337 Entrez Gene: 203228

Expression Profile of C9orf72 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-142-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-188-5p YES NO YES hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-24-3p YES YES NO hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-541-3p YES NO NO hsa-miR-654-5p YES NO NO hsa-miR-93-5p YES YES NO Display: