| ncRNA Symbol: | ARAP1 | | Full Name: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | | Category: | mRNA | | Synonyms: | CENTD2 | | Chromosome: | chr11 | | Strand: | - | | Coordinate: | | Start Site(bp): | 72685069 | End Site(bp): | 72793599 |
| | Gene Summary: | The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] | | External Links: | |
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