ctcRbase

Entry Detail

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General Information

Database ID: PRAD04612 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: LZTFL1 Full Name: leucine zipper transcription factor like 1 Category: mRNA Synonyms: BBS17 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 45823316 End Site(bp): 45916042 Gene Summary: This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013] External Links: Ensembl ID: ENSG00000163818 HGNC ID: HGNC:6741 Entrez Gene: 54585

Expression Profile of LZTFL1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-590-5p YES YES NO Display: