ctcRbase

Entry Detail

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General Information

Database ID: PRAD04635 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: NRAS Full Name: NRAS proto-oncogene, GTPase Category: mRNA Synonyms: ALPS4|CMNS|N-ras|NCMS|NRAS1|NS6 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 114704469 End Site(bp): 114716894 Gene Summary: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] External Links: Ensembl ID: ENSG00000213281 HGNC ID: HGNC:7989 Entrez Gene: 4893

Expression Profile of NRAS Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-124-3p YES YES YES hsa-miR-143-3p NO YES YES hsa-miR-144-3p YES YES NO hsa-miR-145-5p NO YES YES hsa-miR-146a-5p YES YES YES hsa-miR-146b-5p YES YES YES hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-152-3p YES NO YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-183-5p NO YES YES hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-218-5p YES YES NO hsa-miR-22-3p NO YES YES hsa-miR-224-5p YES YES NO hsa-miR-25-3p NO YES YES hsa-miR-28-5p YES YES YES hsa-miR-29a-3p NO YES YES hsa-miR-29b-3p NO YES YES hsa-miR-29c-3p NO YES YES hsa-miR-32-5p NO YES YES hsa-miR-326 YES NO YES hsa-miR-330-5p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-363-3p NO YES YES hsa-miR-367-3p NO YES YES hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-708-5p YES YES YES hsa-miR-760 YES NO YES hsa-miR-92a-3p NO YES YES hsa-miR-92b-3p NO YES YES hsa-miR-98-5p YES YES YES Display: