ctcRbase

Entry Detail

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General Information

Database ID: PRAD04787 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CSK Full Name: C-terminal Src kinase Category: mRNA Synonyms: - Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 74782057 End Site(bp): 74803198 Gene Summary: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000103653 HGNC ID: HGNC:2444 Entrez Gene: 1445

Expression Profile of CSK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-24-3p YES NO YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-342-3p YES NO YES hsa-miR-346 YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-485-5p YES YES NO Display: