ctcRbase

Entry Detail

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General Information

Database ID: PRAD06376 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: AUH Full Name: AU RNA binding methylglutaconyl-CoA hydratase Category: mRNA Synonyms: - Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 91213815 End Site(bp): 91361913 Gene Summary: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000148090 HGNC ID: HGNC:890 Entrez Gene: 549

Expression Profile of AUH Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-9-5p YES YES YES Display: