| ncRNA Symbol: | RBFOX1 |
| Full Name: | RNA binding fox-1 homolog 1 |
| Category: | mRNA |
| Synonyms: | 2BP1|A2BP1|FOX-1|FOX1|HRNBP1 |
| Chromosome: | chr16 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 5239802 | End Site(bp): | 7713338 |
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| Gene Summary: | The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
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