| ncRNA Symbol: | ACKR2 |
| Full Name: | atypical chemokine receptor 2 |
| Category: | mRNA |
| Synonyms: | CCBP2|CCR10|CCR9|CMKBR9|D6|hD6 |
| Chromosome: | chr3 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 42804752 | End Site(bp): | 42887974 |
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| Gene Summary: | This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008] |
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