ctcRbase

Entry Detail

---



General Information

Database ID: PRAD06762 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PANK2 Full Name: pantothenate kinase 2 Category: mRNA Synonyms: C20orf48|HARP|HSS|NBIA1|PKAN Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 3888839 End Site(bp): 3929882 Gene Summary: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000125779 HGNC ID: HGNC:15894 Entrez Gene: 80025

Expression Profile of PANK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-151a-3p YES NO YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-342-3p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-433-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-876-5p YES YES NO Display: