ctcRbase

Entry Detail

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General Information

Database ID: PRAD06912 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: BCR Full Name: BCR, RhoGEF and GTPase activating protein Category: mRNA Synonyms: ALL|BCR1|CML|D22S11|D22S662|PHL Chromosome: chr22 Strand: + Coordinate: Start Site(bp): 23179704 End Site(bp): 23318037 Gene Summary: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000186716 HGNC ID: HGNC:1014 Entrez Gene: 613

Expression Profile of BCR Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-10a-5p YES YES YES hsa-miR-10b-5p YES YES YES hsa-miR-154-5p YES YES NO hsa-miR-17-5p YES NO YES hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-371a-5p YES YES NO hsa-miR-519d-3p YES NO YES hsa-miR-93-5p YES NO YES Display: