| ncRNA Symbol: | RNASE1 | | Full Name: | ribonuclease A family member 1, pancreatic | | Category: | mRNA | | Synonyms: | RAC1|RIB1|RNS1 | | Chromosome: | chr14 | | Strand: | - | | Coordinate: | | Start Site(bp): | 20801228 | End Site(bp): | 20803278 |
| | Gene Summary: | This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] | | External Links: | |
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