ctcRbase

Entry Detail

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General Information

Database ID: PRAD07974 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: TLR4 Full Name: toll like receptor 4 Category: mRNA Synonyms: ARMD10|CD284|TLR-4|TOLL Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 117704332 End Site(bp): 117716871 Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] External Links: Ensembl ID: ENSG00000136869 HGNC ID: HGNC:11850 Entrez Gene: 7099

Expression Profile of TLR4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-145-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-590-5p YES YES NO Display: