ctcRbase

Entry Detail

---



General Information

Database ID: PRAD08480 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: IL6R Full Name: interleukin 6 receptor Category: mRNA Synonyms: CD126|IL-6R-1|IL-6RA|IL6Q|IL6RA|IL6RQ|gp80 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 154405193 End Site(bp): 154469450 Gene Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] External Links: Ensembl ID: ENSG00000160712 HGNC ID: HGNC:6019 Entrez Gene: 3570

Expression Profile of IL6R Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-137 YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-143-3p YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-491-5p YES YES NO hsa-miR-496 YES YES NO hsa-miR-653-5p YES YES NO Display: