ctcRbase

Entry Detail

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General Information

Database ID: PRAD08815 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PLA2G4A Full Name: phospholipase A2 group IVA Category: mRNA Synonyms: PLA2G4|cPLA2|cPLA2-alpha Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 186828953 End Site(bp): 186988981 Gene Summary: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] External Links: Ensembl ID: ENSG00000116711 HGNC ID: HGNC:9035 Entrez Gene: 5321

Expression Profile of PLA2G4A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-145-5p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-410-3p YES YES YES hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-543 YES YES YES Display: