ctcRbase

Entry Detail

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General Information

Database ID: PRAD09138 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PRKCA Full Name: protein kinase C alpha Category: mRNA Synonyms: AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 66302636 End Site(bp): 66810743 Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000154229 HGNC ID: HGNC:9393 Entrez Gene: 5578

Expression Profile of PRKCA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-139-5p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-147a YES NO NO hsa-miR-150-5p YES NO YES hsa-miR-154-5p YES YES YES hsa-miR-183-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-200b-3p YES NO YES hsa-miR-200c-3p YES NO YES hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES NO YES hsa-miR-24-3p YES NO YES hsa-miR-329-3p YES NO YES hsa-miR-340-5p YES NO YES hsa-miR-362-3p YES NO YES hsa-miR-362-5p YES NO YES hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-429 YES NO YES hsa-miR-495-3p YES NO YES hsa-miR-532-3p YES NO YES hsa-miR-599 YES YES NO hsa-miR-9-5p YES NO YES Display: