| ncRNA Symbol: | IDO1 | | Full Name: | indoleamine 2,3-dioxygenase 1 | | Category: | mRNA | | Synonyms: | IDO|IDO-1|INDO | | Chromosome: | chr8 | | Strand: | + | | Coordinate: | | Start Site(bp): | 39902275 | End Site(bp): | 39928444 |
| | Gene Summary: | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] | | External Links: | |
|