ctcRbase

Entry Detail

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General Information

Database ID: PRAD09541 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PHLPP1 Full Name: PH domain and leucine rich repeat protein phosphatase 1 Category: mRNA Synonyms: PHLPP|PLEKHE1|PPM3A|SCOP Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 62715450 End Site(bp): 62980433 Gene Summary: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011] External Links: Ensembl ID: ENSG00000081913 HGNC ID: HGNC:20610 Entrez Gene: 23239

Expression Profile of PHLPP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106b-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-141-3p YES YES YES hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-224-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-375 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-93-5p YES YES NO Display: