ctcRbase

Entry Detail

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General Information

Database ID: PRAD10187 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PTCH1 Full Name: patched 1 Category: mRNA Synonyms: BCNS|NBCCS|PTC|PTC1|PTCH Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 95442980 End Site(bp): 95517057 Gene Summary: This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000185920 HGNC ID: HGNC:9585 Entrez Gene: 5727

Expression Profile of PTCH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES NO YES hsa-miR-140-3p YES NO YES hsa-miR-144-3p YES NO YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-190a-5p YES NO YES hsa-miR-190b YES NO YES hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-212-3p YES NO YES hsa-miR-296-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-425-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-448 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-499a-5p YES YES NO hsa-miR-503-5p YES NO NO hsa-miR-543 YES YES NO hsa-miR-802 YES NO YES hsa-miR-9-5p YES NO YES Display: