ctcRbase

Entry Detail

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General Information

Database ID: PRAD10352 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: HGF Full Name: hepatocyte growth factor Category: mRNA Synonyms: DFNB39|F-TCF|HGFB|HPTA|SF Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 81699006 End Site(bp): 81770438 Gene Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015] External Links: Ensembl ID: ENSG00000019991 HGNC ID: HGNC:4893 Entrez Gene: 3082

Expression Profile of HGF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7g-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-195-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-338-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-98-5p YES YES NO Display: