ctcRbase

Entry Detail

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General Information

Database ID: PRAD10953 Cancer Type: prostate cancer Dataset: GSE67980 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CBS Full Name: cystathionine-beta-synthase Category: mRNA Synonyms: CBSL|HIP4 Chromosome: chr21 Strand: - Coordinate: Start Site(bp): 43053191 End Site(bp): 43076943 Gene Summary: The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016] External Links: Ensembl ID: ENSG00000160200 HGNC ID: HGNC:1550 Entrez Gene: 875

Expression Profile of CBS Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-494-3p YES YES YES hsa-miR-542-3p YES YES NO hsa-miR-7-5p YES YES NO Display: