ctcRbase

Entry Detail

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General Information

Database ID: PRAD11049 Cancer Type: prostate cancer Dataset: GSE67980 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: SOCS2 Full Name: suppressor of cytokine signaling 2 Category: mRNA Synonyms: CIS2|Cish2|SOCS-2|SSI-2|SSI2|STATI2 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 93569814 End Site(bp): 93583487 Gene Summary: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000120833 HGNC ID: HGNC:19382 Entrez Gene: 8835

Expression Profile of SOCS2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-194-5p YES YES YES hsa-miR-196a-5p NO YES YES hsa-miR-196b-5p NO YES YES hsa-miR-200a-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-7-5p YES YES YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: