ctcRbase

Entry Detail

---



General Information

Database ID: PRAD11340 Cancer Type: prostate cancer Dataset: GSE67980 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: SRF Full Name: serum response factor Category: mRNA Synonyms: MCM1 Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 43171299 End Site(bp): 43181507 Gene Summary: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] External Links: Ensembl ID: ENSG00000112658 HGNC ID: HGNC:11291 Entrez Gene: 6722

Expression Profile of SRF Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-147a YES NO NO hsa-miR-149-5p YES NO YES hsa-miR-154-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-296-5p YES NO YES hsa-miR-300 YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-335-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-365a-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-496 YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-7-5p YES YES NO hsa-miR-9-5p YES NO YES Display: