ctcRbase

Entry Detail

---



General Information

Database ID: SKCM00442 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GPNMB Full Name: glycoprotein nmb Category: mRNA Synonyms: HGFIN|NMB|PLCA3 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 23235967 End Site(bp): 23275108 Gene Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000136235 HGNC ID: HGNC:4462 Entrez Gene: 10457

Expression Profile of GPNMB Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-422a YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-873-5p YES YES NO Display: