ctcRbase

Entry Detail

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General Information

Database ID: SKCM00549 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: COPS8 Full Name: COP9 signalosome subunit 8 Category: mRNA Synonyms: COP9|CSN8|SGN8 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 237085312 End Site(bp): 237100466 Gene Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000198612 HGNC ID: HGNC:24335 Entrez Gene: 10920

Expression Profile of COPS8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-223-3p YES NO YES hsa-miR-342-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-429 YES YES YES hsa-miR-495-3p YES YES NO Display: