Entry Detail



General Information

Database ID:SKCM00564
Cancer Type:melanoma
Dataset:GSE38495
CTCs/CTM Isolation Method:immunomagnetic purification



Gene Information

ncRNA Symbol:PRAME
Full Name:preferentially expressed antigen in melanoma
Category:mRNA
Synonyms:CT130|MAPE|OIP-4|OIP4
Chromosome:chr22
Strand:-
Coordinate:
Start Site(bp):22547701End Site(bp):22559361
Gene Summary:This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
External Links:
Ensembl ID:ENSG00000185686
HGNC ID:HGNC:9336
Entrez Gene:23532



Expression Profile of PRAME Gene

 







Regulatory Relationship

mRNA targets:NA
miRNA targets:
miRNA NamePITAmiRandaRNAhybrid
hsa-miR-204-5p
YES
YES
NO
hsa-miR-211-5p
YES
YES
NO
hsa-miR-23a-3p
YES
YES
NO
hsa-miR-23b-3p
YES
YES
NO
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