ctcRbase

Entry Detail

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General Information

Database ID: SKCM00956 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: HNMT Full Name: histamine N-methyltransferase Category: mRNA Synonyms: HMT|HNMT-S1|HNMT-S2|MRT51 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 137964020 End Site(bp): 138016364 Gene Summary: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000150540 HGNC ID: HGNC:5028 Entrez Gene: 3176

Expression Profile of HNMT Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-206 YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-223-3p YES NO YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-613 YES YES NO hsa-miR-653-5p YES YES NO Display: