ctcRbase

Entry Detail

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General Information

Database ID: SKCM00977 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PAICS Full Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Category: mRNA Synonyms: ADE2|ADE2H1|AIRC|PAIS Chromosome: chr4 Strand: + Coordinate: Start Site(bp): 56435741 End Site(bp): 56464579 Gene Summary: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000128050 HGNC ID: HGNC:8587 Entrez Gene: 10606

Expression Profile of PAICS Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-422a YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-653-5p YES YES NO Display: