| ncRNA Symbol: | DPH3 |
| Full Name: | diphthamide biosynthesis 3 |
| Category: | mRNA |
| Synonyms: | DELGIP|DELGIP1|DESR1|DPH3A|KTI11|ZCSL2 |
| Chromosome: | chr3 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 16257978 | End Site(bp): | 16264972 |
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| Gene Summary: | This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] |
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