ctcRbase

Entry Detail

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General Information

Database ID: SKCM01125 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TIMP2 Full Name: TIMP metallopeptidase inhibitor 2 Category: mRNA Synonyms: CSC-21K|DDC8 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 78852977 End Site(bp): 78925387 Gene Summary: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000035862 HGNC ID: HGNC:11821 Entrez Gene: 7077

Expression Profile of TIMP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-191-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-218-5p YES YES NO hsa-miR-221-3p YES NO YES hsa-miR-222-3p YES NO YES hsa-miR-223-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-378a-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-422a YES YES NO hsa-miR-429 YES YES YES hsa-miR-431-5p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-454-3p YES YES YES hsa-miR-455-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-495-3p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-655-3p YES NO YES hsa-miR-93-5p YES YES YES Display: