ctcRbase

Entry Detail

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General Information

Database ID: SKCM01162 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DFFA Full Name: DNA fragmentation factor subunit alpha Category: mRNA Synonyms: DFF-45|DFF1|ICAD Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 10456522 End Site(bp): 10472526 Gene Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000160049 HGNC ID: HGNC:2772 Entrez Gene: 1676

Expression Profile of DFFA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-193a-5p YES NO YES hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-339-5p YES YES YES hsa-miR-34a-5p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-873-5p YES YES NO Display: