ctcRbase

Entry Detail

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General Information

Database ID: SKCM01228 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: HUS1 Full Name: HUS1 checkpoint clamp component Category: mRNA Synonyms: hHUS1 Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 47695730 End Site(bp): 47979581 Gene Summary: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011] External Links: Ensembl ID: ENSG00000136273 HGNC ID: HGNC:5309 Entrez Gene: 3364

Expression Profile of HUS1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1323 YES NO NO hsa-miR-143-3p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-542-3p YES YES NO hsa-miR-548o-3p YES NO NO Display: