ctcRbase

Entry Detail

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General Information

Database ID: SKCM01355 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MCM3 Full Name: minichromosome maintenance complex component 3 Category: mRNA Synonyms: HCC5|P1-MCM3|P1.h|RLFB Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 52264009 End Site(bp): 52284881 Gene Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018] External Links: Ensembl ID: ENSG00000112118 HGNC ID: HGNC:6945 Entrez Gene: 4172

Expression Profile of MCM3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-543 YES YES NO hsa-miR-93-5p YES YES YES Display: