ctcRbase

Entry Detail

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General Information

Database ID: SKCM03829 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CREBL2 Full Name: cAMP responsive element binding protein like 2 Category: mRNA Synonyms: - Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 12611827 End Site(bp): 12645108 Gene Summary: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000111269 HGNC ID: HGNC:2350 Entrez Gene: 1389

Expression Profile of CREBL2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1297 YES YES YES hsa-miR-1-3p YES NO YES hsa-miR-143-3p YES YES YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-151a-3p YES NO NO hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-206 YES NO YES hsa-miR-211-5p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-216a-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-24-3p YES NO YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-28-3p YES NO NO hsa-miR-28-5p YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-330-3p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-424-5p YES NO YES hsa-miR-429 YES YES NO hsa-miR-483-3p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-503-5p YES YES NO hsa-miR-543 YES YES YES hsa-miR-590-5p YES YES YES hsa-miR-613 YES NO YES hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-708-5p YES YES NO Display: