ctcRbase

Entry Detail

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General Information

Database ID: SKCM04324 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ROCK1 Full Name: Rho associated coiled-coil containing protein kinase 1 Category: mRNA Synonyms: P160ROCK|ROCK-I Chromosome: chr18 Strand: - Coordinate: Start Site(bp): 20946906 End Site(bp): 21111851 Gene Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015] External Links: Ensembl ID: ENSG00000067900 HGNC ID: HGNC:10251 Entrez Gene: 6093

Expression Profile of ROCK1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-101-3p YES YES YES hsa-miR-1251-5p YES NO YES hsa-miR-129-5p YES NO YES hsa-miR-1297 YES NO YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-132-3p YES NO YES hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-136-5p YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-145-5p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-150-5p YES NO YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-186-5p YES NO YES hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-212-3p YES NO YES hsa-miR-217 YES YES YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-299-5p YES NO YES hsa-miR-300 YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-324-5p YES YES YES hsa-miR-335-5p YES YES YES hsa-miR-33a-5p YES NO YES hsa-miR-33b-5p YES NO YES hsa-miR-340-5p YES YES YES hsa-miR-346 YES NO YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-361-5p YES NO YES hsa-miR-371a-5p NO YES YES hsa-miR-376c-3p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-421 YES YES YES hsa-miR-431-5p YES YES YES hsa-miR-448 YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-487a-3p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-532-3p YES NO YES hsa-miR-582-5p YES NO YES hsa-miR-599 YES YES NO hsa-miR-98-5p YES YES NO Display: