ctcRbase

Entry Detail

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General Information

Database ID: SKCM04411 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CASP8 Full Name: caspase 8 Category: mRNA Synonyms: ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 201233443 End Site(bp): 201287711 Gene Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000064012 HGNC ID: HGNC:1509 Entrez Gene: 841

Expression Profile of CASP8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-105-5p YES NO NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-128-3p NO YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-1323 YES NO NO hsa-miR-134-5p NO YES YES hsa-miR-142-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-187-3p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-27a-3p NO YES YES hsa-miR-27b-3p NO YES YES hsa-miR-29a-3p NO YES NO hsa-miR-29b-3p NO YES NO hsa-miR-29c-3p NO YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-421 NO YES YES hsa-miR-454-3p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-543 YES YES NO hsa-miR-548o-3p YES NO NO hsa-miR-590-5p YES YES NO hsa-miR-93-5p YES YES NO Display: