ctcRbase

Entry Detail

---



General Information

Database ID: SKCM04427 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DLG5 Full Name: discs large MAGUK scaffold protein 5 Category: mRNA Synonyms: LP-DLG|P-DLG5|PDLG Chromosome: chr10 Strand: - Coordinate: Start Site(bp): 77790791 End Site(bp): 77926526 Gene Summary: This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000151208 HGNC ID: HGNC:2904 Entrez Gene: 9231

Expression Profile of DLG5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-10a-5p YES NO YES hsa-miR-10b-5p YES NO YES hsa-miR-124-3p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-144-3p YES NO YES hsa-miR-150-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-188-5p YES NO YES hsa-miR-192-5p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-215-5p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-665 YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: