ctcRbase

Entry Detail

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General Information

Database ID: SKCM04552 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PTPN21 Full Name: protein tyrosine phosphatase, non-receptor type 21 Category: mRNA Synonyms: PTPD1|PTPRL10 Chromosome: chr14 Strand: - Coordinate: Start Site(bp): 88465778 End Site(bp): 88554733 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000070778 HGNC ID: HGNC:9651 Entrez Gene: 11099

Expression Profile of PTPN21 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-28-5p YES YES NO hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-338-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-455-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-708-5p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-874-3p YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-96-5p YES YES NO Display: