ctcRbase

Entry Detail

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General Information

Database ID: SKCM04687 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ATP2B4 Full Name: ATPase plasma membrane Ca2+ transporting 4 Category: mRNA Synonyms: ATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4x Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 203626561 End Site(bp): 203744081 Gene Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000058668 HGNC ID: HGNC:817 Entrez Gene: 493

Expression Profile of ATP2B4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-129-5p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES NO YES hsa-miR-181b-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-183-5p YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES NO YES hsa-miR-187-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-206 YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-330-3p YES NO YES hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-376c-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-411-5p YES YES YES hsa-miR-448 YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-590-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-96-5p YES YES YES hsa-miR-98-5p YES NO YES Display: