ctcRbase

Entry Detail

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General Information

Database ID: SKCM04819 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: APC Full Name: APC, WNT signaling pathway regulator Category: mRNA Synonyms: BTPS2|DP2|DP2.5|DP3|GS|PPP1R46 Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 112707498 End Site(bp): 112846239 Gene Summary: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000134982 HGNC ID: HGNC:583 Entrez Gene: 324

Expression Profile of APC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-129-5p YES YES YES hsa-miR-1298-5p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-142-3p YES YES YES hsa-miR-144-3p YES NO YES hsa-miR-150-5p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-155-5p YES NO YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-208a-3p YES YES YES hsa-miR-208b-3p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-299-3p YES YES NO hsa-miR-300 YES YES YES hsa-miR-330-3p YES NO YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-448 YES YES YES hsa-miR-487a-3p YES NO YES hsa-miR-494-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-499a-5p YES YES YES hsa-miR-501-3p YES NO YES hsa-miR-502-3p YES NO YES hsa-miR-503-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-582-5p YES NO YES hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES Display: