ctcRbase

Entry Detail

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General Information

Database ID: SKCM04927 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RUBCN Full Name: RUN and cysteine rich domain containing beclin 1 interacting protein Category: mRNA Synonyms: KIAA0226|RUBICON|SCAR15 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 197671393 End Site(bp): 197749727 Gene Summary: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014] External Links: Ensembl ID: ENSG00000145016 HGNC ID: HGNC:28991 Entrez Gene: 9711

Expression Profile of RUBCN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-143-3p YES YES NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-15a-5p YES NO YES hsa-miR-15b-5p YES NO YES hsa-miR-16-5p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES NO YES hsa-miR-197-3p YES YES NO hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-205-5p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-211-5p YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-24-3p YES YES YES hsa-miR-302a-3p YES NO YES hsa-miR-302b-3p YES NO YES hsa-miR-302c-3p YES NO YES hsa-miR-302d-3p YES NO YES hsa-miR-302e YES NO YES hsa-miR-31-5p YES NO YES hsa-miR-329-3p YES NO NO hsa-miR-362-3p YES NO NO hsa-miR-365a-3p YES YES NO hsa-miR-372-3p YES NO YES hsa-miR-373-3p YES NO YES hsa-miR-424-5p YES NO YES hsa-miR-431-5p YES YES NO hsa-miR-497-5p YES NO YES hsa-miR-506-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES NO YES hsa-miR-520b YES NO YES hsa-miR-520c-3p YES NO YES hsa-miR-520d-3p YES NO YES hsa-miR-520e YES NO YES hsa-miR-520f-3p YES NO YES hsa-miR-873-5p YES YES NO hsa-miR-93-5p YES YES YES Display: